PFAS Protein Interaction Targets from Thermal Proteome Profiling

Thermal proteome profiling data identifies 173 proteins with significant ligand-induced stabilization across five representative PFAS chemicals. The dataset, generated by Xuehan Zheng and published in 2026, links stabilized targets to 279 standardized disease entities, predominantly neoplastic outcomes.

Use Cases

• Analyze the distinct targetome, highlighted by WDR89, for the replacement ether PFAS HFPO–DA (GenX) versus legacy PFAS.
• Investigate the convergence of legacy PFAS on small COPII coat GTPase SAR1A/SAR1B for mechanistic insights.
• Map the 173 identified proteins with significant ligand-induced stabilization to their associated 279 disease entities for risk assessment.
• Use molecular docking and cellular thermal shift assay results to validate target engagement and structural stabilization patterns.

Strengths

• Identifies 173 specific proteins with significant ligand-induced stabilization.
• Links protein targets to 279 standardized disease entities for contextual analysis.
• Compares target profiles across five representative PFAS, including legacy and replacement chemistries.

Limitations

• Dataset size is 6.0 MB, indicating a relatively small scale of experimental results.
• Sample data and column structure are unavailable, limiting immediate analytical exploration.
• Focus is on in vitro protein interactions, requiring complementary data for in vivo toxicological validation.

Provenance

Source

figshare, author Xuehan Zheng.

Collection Method

Generated via thermal proteome profiling (TPP) applied for unbiased, proteome-wide characterization of PFAS–protein interactions.

Time Range

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Freshness

Last updated March 2026.

Geography

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