Genetic Association Data for Kidney Function and Hearing Performance

A 24.1 MB dataset by Weiling Huang from 2026 contains summary statistics from a bidirectional two-sample Mendelian randomization study. It examines the causal relationship between genetically predicted kidney function traits and speech reception threshold using data from the CKDGen Consortium and UK Biobank. The study found no robust genetic evidence supporting a causal link, suggesting observed epidemiological associations may stem from shared systemic or environmental factors.

Use Cases

• Conducting Mendelian randomization sensitivity analyses based on the described IVW, MR-Egger, weighted median, and mode-based estimators.
• Investigating pleiotropy in genetic studies based on the described sensitivity analyses for directional horizontal pleiotropy.
• Replicating causal inference studies on kidney-hearing associations based on the genetic instruments for eGFR, CKD, and BUN.
• Benchmarking MR methodologies using a dataset with nominally significant but non-robust associations as described.

Strengths

• Data is derived from large-scale genome-wide association studies by the CKDGen Consortium and UK Biobank.
• Analysis employs multiple Mendelian randomization estimators (IVW, MR-Egger, weighted median, mode-based) for robustness.
• Dataset is licensed under CC-BY-4.0, facilitating open reuse and sharing.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The description indicates no robust causal associations were identified, which may limit utility for hypothesis-confirming studies.

Provenance

Source

CKDGen Consortium and UK Biobank.

Collection Method

Bidirectional two-sample Mendelian randomization analysis using genetic instruments.

Freshness

Last updated 2026-05-15 03:52:24; freshness should be verified.