A systematic review of 123 hypothesis-testing studies evaluating the safety of multi-dose vaccines in the post-licensure phase. The dataset, authored by Monica Mtei and last updated in April 2026, analyzes design and analytical approaches from studies published between 2018 and 2022. It identifies the prevalence of cohort, self-controlled case series, and case-control designs and reports on methodological reporting gaps.
Use Cases
- Benchmarking methodological approaches in vaccine safety studies based on the reported prevalence of cohort, SCCS, and case-control designs.
- Identifying common reporting gaps in observational studies based on the finding that 28% of cohort studies did not clearly report time zero.
- Analyzing strategies for addressing event-dependent exposures based on the review of methods used in SCCS/SCRI studies.
- Assessing agreement between different study designs based on the finding that 68% of studies using multiple designs reached consistent conclusions.
Strengths
- Analyzes a specific corpus of 123 eligible studies, providing a quantitative basis.
- Reports precise percentages for study design usage (e.g., cohort 46%, SCCS/SCRI 40%).
- Covers a defined time range of studies published from 2018 to 2022.
Limitations
- Row count is unknown, which may limit suitability assessment.
- Column-level documentation is absent; field semantics must be inferred after download.
- The dataset is small at 457.2 KB, indicating limited scope.
Provenance
- Source
- figshare
- Collection Method
- Systematic review of EMBASE, MEDLINE, Web of Science, and Scopus.
- Time Range
- 2018-2022
- Freshness
- Last updated 2026-04-30 08:29:01; freshness should be verified.
- Geography
- null