Aryl Sulfamoyl [18F]Fluorides: Synthesis and PET Tracer Assessment Data

Jan Bertram published data on the radiosynthesis of N-aryl sulfamoyl [18F]fluorides via base-free SuFEx on 2026-05-07. The dataset, 3.3 KB in size, likely contains results from in vitro stability tests across pH ranges and in human plasma, as well as in vivo studies in mice and cellular uptake comparisons in U87 MG glioblastoma cells.

Use Cases

• Evaluating novel radiotracer stability based on in vitro and in vivo results mentioned in the description
• Comparing cellular uptake efficiency of new compounds against a gold standard ([18F]FET) based on the glioblastoma cell line experiments
• Assessing the impact of molecular structure (e.g., N-alkyl-N-aryl vs. indole derivatives) on in vivo defluorination rates
• Optimizing SuFEx radiosynthesis protocols for high molar activity from nanomolar precursors

Strengths

• Data is associated with a specific, peer-reviewed-sounding research methodology: base-free sulfur(VI) fluoride exchange (SuFEx) radiosynthesis.
• The description reports concrete experimental outcomes, such as 'excellent in vitro stability across a wide pH range' and 'up to 2–3-fold higher cellular uptake' in specific cell lines.
• Published under a clear CC-BY-NC-4.0 license, defining permissible reuse.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (3.3 KB), indicating limited scope, likely a summary of key results rather than raw experimental data.
• Description metadata is limited; actual data quality and completeness require manual inspection after download.

Provenance

Source

figshare, author Jan Bertram

Collection Method

Likely contains experimental results from radiochemical synthesis and biological assessment.

Time Range

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Freshness

Last updated 2026-05-07 19:33:31; freshness should be verified.

Geography

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