Oral Microbiota and Asthma Causal Links from East Asian GWAS

Zi-Feng Wei's dataset presents results from a two-sample Mendelian randomization analysis investigating causal links between oral microbiota and asthma in an East Asian population. The analysis examined 3,117 bacterial taxa, identifying 18 oral microbiota across nine genera with significant causal effects. Findings include 12 positive and 6 negative causal associations, with enrichment noted in the genera Parvimonas, Streptococcus, and TM7x.

Use Cases

• Testing causal hypotheses between specific oral bacterial genera and asthma risk using Mendelian randomization results.
• Replicating or validating genetic instrumental variable analyses for microbiome-disease relationships.
• Investigating population-specific (East Asian) genetic links to oral microbiome composition and asthma.
• Conducting secondary analyses on the identified 18 causal oral microbiota taxa for meta-studies.

Strengths

• Analysis is based on a substantial scale of 3,117 bacterial taxa.
• Employs multiple Mendelian randomization methods (IVW, MR-Egger, weighted median, weighted mode) and reports tests for pleiotropy and heterogeneity.
• Dataset is openly shared under a CC-BY-4.0 license, facilitating reuse.

Limitations

• Column names and specific row counts are not provided, limiting understanding of the data structure.
• The dataset appears to contain summary results (PDF), not the underlying raw GWAS or individual-level data.
• The listed update date (2026-03-21) is in the future, indicating a potential metadata error.

Provenance

Source

Zi-Feng Wei

Collection Method

Two-sample Mendelian randomization analysis using Genome-Wide Association Study (GWAS) data.

Time Range

null

Freshness

Last updated 2026-03-21 14:25:12 (note: future date).

Geography

East Asian population