Association between miR-155 and Th17/Treg Balance in Unexplained Recurrent Pregnancy Loss

A single-centre retrospective study analysed 189 patients with unexplained recurrent pregnancy loss (URPL) and 91 healthy pregnant women. The dataset likely contains measurements of serum miR-155 expression, Th17 and Treg cell counts, and related cytokines to explore their association with adverse pregnancy outcomes. The study was authored by Yingqiong Chen and last updated on 2026-05-19.

Use Cases

• Predicting adverse pregnancy outcomes in URPL patients based on miR-155 expression levels mentioned in the description
• Analyzing correlations between miR-155 and Th17/Treg cell ratios described in the study
• Evaluating the discriminatory performance of miR-155 as a biomarker using ROC curve analysis detailed in the description
• Investigating factors associated with pregnancy loss via logistic regression models on cytokine and cell count data

Strengths

• Includes data from 280 total participants (189 URPL patients and 91 controls), providing a defined cohort size
• Measures multiple immunological variables: miR-155, Th17 cells, Treg cells, and six cytokines (IL-17, IL-6, IL-10, TGF-β1)
• Reports specific statistical results, such as an AUC of 0.801 for miR-155's discriminatory performance for APOs

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is from a single-centre retrospective study, which may limit generalizability

Provenance

Source

figshare

Collection Method

Single-centre retrospective clinical study

Freshness

Last updated 2026-05-19 19:09:02; freshness should be verified