Association between Plasma Big Endothelin-1 Level and The Severity of Coronary Artery Dise

766 patients with non-ST segment-elevation myocardial infarction (NSTEMI) were recruited for a study evaluating the association between plasma big endothelin-1 (ET-1) level and the SYNTAX score (SS). The study, authored by Si‐qi Lyu, found a significant correlation (r=0.378) and identified an optimal cutoff of 0.35pmol/l for predicting intermediate-high SS.

Use Cases

• Predicting coronary artery disease severity based on plasma big endothelin-1 levels.
• Evaluating biomarker performance for risk stratification in NSTEMI patients using receiver operating characteristic (ROC) curve analysis.
• Investigating the correlation between a continuous biomarker variable and a clinical scoring system via logistic regression.

Strengths

• Includes data from 766 patients with NSTEMI undergoing coronary angiography.
• Study reports specific statistical results, including a correlation coefficient of r=0.378 and an area under the ROC curve of 0.695.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

paperswithcode

Collection Method

Data likely collected from patients recruited for a clinical study, as described in the abstract.