Association of peripheral blood brain-derived neurotrophic factor (BDNF) levels with the u

Rabiatul Adawiyah Mohamad Noor's systematic review and meta-analysis investigates the association between technology-assisted stroke rehabilitation and blood-based brain-derived neurotrophic factor (BDNF) levels. The work includes 15 studies in the review, with 8 eligible for meta-analysis, covering research published from January 2010 to July 2025. The analysis suggests technology-assisted rehabilitation may influence neural repair biomarkers, though it notes inconsistencies across studies.

Use Cases

• Assessing the effect of technology-assisted rehabilitation on serum BDNF levels based on the reported standardized mean difference (SMD).
• Evaluating the relationship between plasma BDNF levels and rehabilitation technology based on the significant decrease reported in the meta-analysis.
• Identifying research gaps in stroke rehabilitation studies based on the noted inconsistencies and heterogeneous designs.
• Informing the design of longitudinal clinical trials based on the review's conclusions about intervention duration and study quality.

Strengths

• Includes a quantitative meta-analysis of 8 studies on a specific neuroplasticity biomarker (BDNF).
• Systematic review methodology applied to studies from 2010 to 2025, providing a defined temporal scope.
• Results report specific statistical measures, including standardized mean differences (SMDs) and confidence intervals.

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a 48.9 KB document, indicating a limited scope of raw data.

Provenance

Source

Rabiatul Adawiyah Mohamad Noor via figshare.

Collection Method

Systematic review and meta-analysis of studies sourced from PubMed, Scopus, and Cochrane Library.

Time Range

Studies published from January 2010 to July 2025.

Freshness

Last updated 2026-04-30 08:00:03; freshness should be verified.

Geography

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