Serum PFAS and ECG Abnormalities in 3,450 Older Adults

Nan Jiang's dataset on figshare contains results from a cross-sectional, community-based study of 3,450 adults aged 60 years and older. It assesses associations between serum concentrations of per- and polyfluoroalkyl substances (PFAS) and electrocardiographic abnormalities, using Minnesota Code classification and weighted quantile sum regression. The dataset was last updated on March 18, 2026.

Use Cases

• Analyze associations between individual PFAS exposures and ECG abnormality odds based on Minnesota Code classification.
• Investigate mixture effects of combined PFAS exposures using weighted quantile sum regression weights.
• Model exposure-response relationships for PFAS burden and cardiac electrical intervals like QRS and QTc duration.
• Explore domain-specific associations, such as repolarization metrics linked to 6:2 Cl-PFESA.

Strengths

• Data is derived from a study of 3,450 participants, providing a substantial sample size.
• Analysis integrates population findings with in vitro and in silico evidence for biological plausibility.
• The dataset is small (186.3 KB), ensuring quick download and easy initial inspection.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The cross-sectional study design limits causal inference from the associations presented.

Provenance

Source

figshare, author Nan Jiang.

Collection Method

Cross-sectional, community-based study assessing serum PFAS concentrations and ECG readings.

Freshness

Last updated 2026-03-18 13:33:31.