Asymmetric Synthesis Data for S-Trifluoromethyl Sulfoxide and Sulfoximine Pharmacophores

Na Yeon Kwon published a dataset on figshare in April 2026 detailing asymmetric syntheses of chiral S-trifluoromethyl sulfoxides and sulfoximines. The dataset, 44.8 MB in size, likely contains experimental data on copper-catalyzed reactions and mechanistic studies. It was created to address the underexplored preparation of these pharmacophores, which are present in many drugs and clinical candidates.

Use Cases

• Training predictive models for reaction outcomes based on the described copper-catalyzed S-trifluoromethylation process.
• Analyzing the stereochemical outcomes (inversion vs. retention) of sulfilimine conversion reactions described in the mechanistic studies.
• Benchmarking new asymmetric synthesis methods against the reported routes for preparing S-trifluoromethyl sulfoxides and sulfoximines.

Strengths

• Dataset is 44.8 MB, suggesting a contained and manageable file size.
• Description provides a detailed scientific context for the synthetic methods and their pharmaceutical relevance.
• License is clearly specified as CC-BY-NC-4.0.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect the specific experimental bias inherent to the single-author research project on figshare.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from laboratory synthesis and mechanistic studies.

Time Range

Publication date is 2026-04-27.

Freshness

Last updated 2026-04-27 19:43:51; freshness should be verified.

Geography

Organization is unknown; geographic coverage cannot be determined.