Asymmetric Synthesis Data for S-Trifluoromethyl Sulfoxide and Sulfoximine Pharmacophores

A dataset from figshare by Na Yeon Kwon, last updated in April 2026. The data likely contains experimental results for the asymmetric synthesis of chiral S-trifluoromethyl sulfoxides and sulfoximines, which are pharmacophores used in drug development. The 26.1 MB ZIP file includes methods for synthesis and mechanistic studies.

Use Cases

• Training predictive models for reaction outcomes based on described synthesis methods.
• Analyzing structure-activity relationships for S-trifluoromethyl pharmacophores mentioned in the description.
• Benchmarking computational chemistry methods against experimental asymmetric synthesis data.
• Identifying novel synthetic routes for chiral sulfoxides and sulfoximines based on the reported copper-catalyzed trifluoromethylation.

Strengths

• Data is associated with a specific, peer-reviewed research methodology described in the summary.
• Includes synthesis data for complex drug and natural product derivatives, as mentioned in the description.
• Released under a CC-BY-NC-4.0 license, permitting non-commercial reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 26.1 MB size suggests a small dataset, potentially limiting statistical power.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from laboratory synthesis and mechanistic studies.

Time Range

Publication date suggests data is from work completed prior to April 2026.

Freshness

Last updated 2026-04-27 19:43:53; freshness should be verified.

Geography

Organization is unknown; geographic coverage cannot be determined.