Tian Siqi's research data, published on figshare in May 2026, demonstrates how inosine monophosphate (IMP) enhances the killing efficacy of aminoglycoside antibiotics against common aquaculture pathogens like Edwardsiella tarda and Vibrio spp. The dataset, 265.4 KB in size, includes files in PDF and XLSX formats. It likely contains experimental results supporting the proposed mechanism where IMP reshapes central carbon metabolism to increase ATP levels, amplifying energy-dependent proteotoxic stress.
Use Cases
- Modeling antibiotic synergy based on metabolic perturbation data mentioned in the description.
- Analyzing bacterial stress response pathways based on the described mechanisms of translation errors and misfolded protein accumulation.
- Investigating host-pathogen interactions in aquaculture settings based on the specified bacterial species.
Strengths
- Data is openly available under a CC-BY-4.0 license.
- Includes raw data in an accessible XLSX format alongside a descriptive PDF.
- Focuses on a specific, described mechanism of action for antibiotic potentiation.
Limitations
- Row count and specific column definitions are unknown, limiting suitability assessment.
- The dataset is small (265.4 KB), indicating a limited experimental scope.
- Column-level documentation is absent; field semantics must be inferred after download.
Provenance
- Source
- figshare
- Collection Method
- Likely contains experimental laboratory data from the described research.
- Freshness
- Last updated 2026-05-26 11:50:27.