Literature Review on Folic Acid Supplementation and Autism Spectrum Disorder Risk

A literature review of 87 articles published between November 2017 and April 2018, examining the link between folic acid supplementation before and during pregnancy and the development of Autism Spectrum Disorder. The work was authored by Carina Scanoni Maia and is available via Open Access. It analyzes studies primarily in Portuguese and English, focusing on the risk-benefit of supplementation at doses of 0.4 to 0.8 mg/day.

Use Cases

• Conducting a meta-analysis on folic acid's role in preventing neural tube defects and ASD based on the reviewed literature.
• Informing clinical guidelines for prenatal care based on the risk-benefit analysis of folic acid supplementation.
• Studying the interplay between genetic factors and nutritional supplementation in neural pathogenesis as discussed in the review.

Strengths

• The review is based on an analysis of 87 articles from a total pool of 174, providing a focused corpus.
• It includes a specific analysis of supplementation at recommended doses of 0.4 to 0.8 mg/day.
• The work is published under an Open Access (green) license, facilitating distribution and reuse.

Limitations

• The underlying dataset of articles is not provided; only the review's abstract and conclusions are available.
• Row count and column-level documentation for any potential data are absent.
• The last update date is unknown, and the temporal coverage of the source literature is limited to a six-month search window.

Provenance

Source

paperswithcode

Collection Method

Literature review conducted in Portuguese and English languages.

Time Range

Source literature search conducted from November 2017 to April 2018.