Research on Dauricine as a Broad-Spectrum PEDV Fusion Inhibitor Targeting the HR1 Domain

Dauricine, a natural alkaloid, is identified as a potent inhibitor of porcine epidemic diarrhea virus (PEDV) entry and membrane fusion. The research includes molecular docking simulations, in vitro functional assays, and efficacy testing in a neonatal piglet model challenged with a virulent G2c strain. The dataset, authored by Wei Hou and last updated in April 2026, contains supporting documentation under a CC-BY-4.0 license.

Use Cases

• Training models for molecular docking affinity prediction based on HR1 domain binding data
• Analyzing time-of-addition experimental profiles characteristic of fusion inhibitors
• Evaluating therapeutic candidate efficacy based on clinical and pathological outcomes in a piglet model

Strengths

• Includes experimental validation in a neonatal piglet model, a relevant in vivo system
• Targets a conserved viral domain (HR1), suggesting potential broad-spectrum application
• Combines computational (molecular docking/dynamics) and functional assay data

Limitations

• Dataset size is 13.2 MB, which may limit the volume of raw experimental data included
• Row count and column-level documentation are absent; data structure must be inferred after download
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

Wei Hou via figshare

Collection Method

Likely contains research data from molecular simulations, in vitro assays, and animal model studies.

Time Range

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Freshness

Last updated 2026-04-30 12:50:21; freshness should be verified

Geography

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