HIL Interference in Clinical Immunoassays Comparing Endogenous and Exogenous Models

Yu Chen presents a dataset quantifying hemolysis, lipemia, and icterus (HIL) interferences across immunoassays. The 1.2 MB collection comprises analytical measurements from electrochemiluminescence and flow fluorescent platforms, contrasting autologous samples with commercial exogenous models. It was last updated on April 30, 2026.

Use Cases

• Assessing the limitations of exogenous interference models based on comparative data with genuine clinical samples.
• Developing correction formulas for hemolysis-sensitive analytes based on the provided derived resources.
• Refining laboratory validation protocols to minimize sample rejections using the dataset's reference charts.
• Studying analytical discrepancies in lipemic samples based on the measured biomarker concentrations.

Strengths

• Dataset size is 1.2 MB, indicating a focused and manageable collection.
• Includes derived reference charts and correction formulas, extending its utility beyond raw data.
• Contrasts two sample preparation methods (autologous/endogenous vs. commercial exogenous), providing a direct comparison.
• Covers a range of biomarkers including interleukins, NSE, folate, insulin, ProGRP, calcitonin, osteocalcin, and total P1NP.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Yu Chen.

Collection Method

Compiled analytical measurements from electrochemiluminescence and flow fluorescent platforms.

Time Range

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Freshness

Last updated 2026-04 30 13:49:13; freshness should be verified.

Geography

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