Longitudinal Single-Cell Transcriptomic Atlas of Bovine Placenta

311,299 placental cells or nuclei from 13 developmental timepoints (E12 to E280) in cows. The dataset identifies 13 major cell types and 14 trophoblast subtypes, mapping cellular hierarchies and regulatory networks during gestation. It was authored by Guanghui Tan and last updated in April 2026.

Use Cases

• Analyze stage-specific expression patterns of trophoblast cells across 13 timepoints to identify key regulators like HAND1 and DLX5.
• Model differentiation trajectories of binucleate cells (BNCs) from uninucleate cell (UNC) subpopulations using imprinted gene and metabolic data.
• Perform integrated GWAS analysis to link early trophoblast subtypes with gestation length (GL) and identify risk genes such as CYCS, HMGA1, and VDAC1.
• Investigate the origin and association of placental macrophages from E30 with pregnancy loss risk pathways shared between cows and humans.

Strengths

• 311,299 single-nucleus transcriptomic profiles provide a substantial cellular resolution.
• Longitudinal coverage across 13 distinct developmental stages from E12 to E280.
• Cell type annotation includes 13 major types and 14 specific trophoblast subtypes.

Limitations

• Data is specific to bovine (cow) biology, limiting direct applicability to other species without careful translation.
• Sample data and specific column schemas are unavailable, complicating initial data exploration.

Provenance

Source

figshare

Collection Method

Single-nucleus RNA sequencing and bioinformatic analysis of bovine placental tissue.

Time Range

Developmental stages E12, E14, E16, E18, E24, E30, E50, E60, E85, E110, E180, E240, E280.

Freshness

Last updated in April 2026.

Geography

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