<b>Amino Acid Substitutions HA P221L and PB2 T521I Increase the Virulence of H3N8 Influenz

Research data from figshare, last updated 2026-05-25, investigates the role of HA-P221L and PB2-T521I amino acid substitutions in enhancing the virulence of H3N8 avian influenza virus in mice. The dataset, licensed under CC-BY-4.0, includes files in DOCX, ZIP, JPG, and XLSX formats totaling 4.6 MB. It provides insights into viral adaptation mechanisms and pandemic risk assessment for currently circulating strains.

Use Cases

• Analyzing the impact of specific amino acid substitutions on viral virulence based on the described HA-P221L and PB2-T521I mutations.
• Modeling viral attachment and internalization mechanisms based on the described role of the HA-P221L substitution.
• Studying viral polymerase activity and host innate immune suppression based on the described function of the PB2-T521I substitution.
• Assessing pandemic risk of circulating avian influenza strains based on the identified virulent phenotype determinants.

Strengths

• Includes experimental data on two previously unreported amino acid substitutions (HA-P221L and PB2-T521I).
• Provides mechanistic insights into viral attachment, polymerase activity, and host immune response.
• Dataset is openly licensed under CC-BY-4.0, facilitating reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect geographic bias inherent to the specific virus strains studied (e.g., A/Chicken/Guangdong/B1157/2022).

Provenance

Source

figshare, author tantao tantao

Collection Method

Likely contains data from serial lung-to-lung passages of H3N8 avian influenza virus in mice.

Time Range

References virus isolates from 2022 and 2023.

Freshness

Last updated 2026-05-25 11:14:43; freshness should be verified.

Geography

Focuses on virus strains from Guangdong, China.