SPP1-SOCS1 Pathway: Bulk and Single-Cell RNA-seq Data for Tumor-Associated Macrophages

814.8 MB of processed bulk and single-cell RNA sequencing data from tumor-associated macrophages and cancer cells, generated by Zemin Zhang and last updated in April 2026. The data supports research into the SPP1-SOCS1 pathway's role in shaping an immunosuppressive tumor microenvironment and resistance to immune checkpoint blockade therapy.

Use Cases

• Analyze gene expression patterns in tumor-associated macrophages based on bulk RNA-seq data
• Investigate cellular heterogeneity and immune cell infiltration based on single-cell transcriptomic data
• Model the relationship between SPP1 expression and immune checkpoint blockade resistance
• Validate findings on the IFN γ-STAT1-ISG pathway regulation in macrophages

Strengths

• Data size is 814.8 MB, indicating substantial content
• Includes both bulk RNA-seq and single-cell transcriptomic data from multiple experimental models
• License is CC-BY-4.0, allowing for open reuse

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Generated from integrated large-scale single-cell sequencing (scRNA-seq) data and processed bulk RNA-seq experiments.

Freshness

Last updated 2026-04-18 05:20:21