Bogalusa Heart Study: Blood Mitochondrial DNA Copy Number Measurements

Gold-standard qPCR-based measurements of blood mitochondrial DNA copy number from participants of the Bogalusa Heart Study. The dataset provides raw, QC-passed values intended for research into early biomarkers for Alzheimer's disease and cognitive decline. Author Yang Pan published this data under a CC-BY-4.0 license, with a last update recorded for April 20, 2026.

Use Cases

• Investigating associations between mitochondrial DNA copy number and midlife cognitive function based on the study's central hypothesis.
• Examining potential mediation effects of mtDNA alterations on the link between cardiovascular risk factors and brain health as described.
• Analyzing raw mtDNA-CN measurements for biomarker discovery related to Alzheimer's disease neurobiological substrates mentioned in the description.

Strengths

• Data values have passed quality control (QC) as stated in the description.
• Measurements are described as 'gold-standard qPCR-based', suggesting a reliable methodology.
• The dataset is associated with the long-running Bogalusa Heart Study, which provides a life-course context.

Limitations

• The dataset represents raw mtDNA-CN and has not been adjusted for batch effects, blood cell composition, or other covariates.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count and file formats are unknown, which may limit suitability assessment.

Provenance

Source

Bogalusa Heart Study (BHS)

Collection Method

qPCR-based measurements from blood samples.

Freshness

Last updated 2026-04-20 21:41:48; freshness should be verified.