Rat Skeletal Muscle Force and Electrophysiology Data with Ketone Body Interventions

Electrophysiological data from isolated soleus and extensor digitorum longus muscles of female Wistar rats. The dataset includes force measurements under elevated potassium and beta-hydroxybutyrate exposure, single-fiber electrophysiology, and control experiments, provided in Excel files with an R markdown script. Author Kristian Overgaard published the data on figshare in 2026.

Use Cases

• Modeling the protective effect of beta-hydroxybutyrate on muscle force based on potassium-induced depression data.
• Analyzing changes in single-fiber electrical properties based on resting membrane conductance and rheobase current measurements.
• Comparing muscle responses between slow-twitch (soleus) and fast-twitch (EDL) fibers under combined lactic acid and salbutamol interventions.

Strengths

• Includes source data for a published study on a specific physiological mechanism.
• Contains multiple data types: force measurements across different stimulation modes and single-fiber electrophysiology parameters.
• Accompanied by an R markdown script for statistical modeling and figure generation, supporting reproducibility.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific experimental model (isolated rat muscle).

Provenance

Source

Kristian Overgaard via figshare.

Collection Method

Experimental data from isolated muscle preparations and single-fiber electrophysiology.

Freshness

Last updated 2026-04-29 18:38:57; freshness should be verified.