BMPR1A in PDLSCs: Mouse and Human Stem Cell Data for Periodontal Bone Homeostasis

A multimodal dataset collected to investigate the role of BMPR1A in Gli1+ periodontal ligament stem cells (PDLSCs) for maintaining periodontal bone homeostasis. The data includes results from conditional knockout mouse models analyzed via µ-CT, histology, and immunohistochemistry, alongside human PDLSC knockdown experiments assessed via TRAP staining, ELISA, western blot, and proteomics. It was authored by Xudong Xie and last updated on May 23, 2026.

Use Cases

• Analyze the effects of BMPR1A knockout on periodontal bone structure based on µ-CT and histology data from mouse models.
• Investigate osteoclast differentiation pathways based on TRAP staining and RANKL/OPG expression data from human PDLSC knockdown experiments.
• Study secretome changes in stem cells based on proteomics data collected from human PDLSCs.
• Compare cell-autonomous bone formation and paracrine suppression of bone resorption based on the dual-role experimental design.

Strengths

• Dataset integrates multiple experimental modalities including µ-CT imaging, histology, immunohistochemistry, TRAP staining, ELISA, western blot, and proteomics.
• Data size is 5.2 GB, indicating substantial raw or processed experimental outputs.
• License is CC-BY-4.0, permitting broad reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific analytical tasks.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare

Collection Method

Generated from conditional knockout mouse experiments and human stem cell knockdown studies, with analysis via µ-CT, histology, immunohistochemistry, TRAP staining, ELISA, western blot, and proteomics.

Freshness

Last updated 2026-05-23 08:43:04; freshness should be verified.