Cardiac Adaptation in a Murine Iliac Arteriovenous Fistula Model

Data from a study on cardiac hypertrophy in male and female C57BL/6J mice with adenine-induced chronic kidney disease following iliac arteriovenous fistula or sham surgery, with or without N-acetylcysteine treatment. The dataset includes ultrasound, echocardiography, and cardiac myocyte mitochondrial respiratory measurements. It was authored by Kyoungrae Kim and last updated on 2026-05-30.

Use Cases

• Investigate sex-specific differences in cardiac remodeling based on echocardiography and heart weight data.
• Analyze the relationship between arteriovenous fistula flow dynamics and left ventricular mass or ejection fraction.
• Evaluate the impact of N-acetylcysteine supplementation on cardiac mitochondrial oxidative phosphorylation.
• Study correlations between cardiac mitochondrial function and echocardiographic parameters like ejection fraction.

Strengths

• Includes specific quantitative results, such as aortic flow increases of +64% in males and +109% in females.
• Reports statistically significant findings (e.g., p=0.001 for heart weight increase).
• Compares multiple experimental groups: sex, surgery type, and treatment.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (110.8 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Experimental data from a murine model study involving surgery, ultrasound, echocardiography, and mitochondrial testing.

Freshness

Last updated 2026-05-30 18:12:28; freshness should be verified.