PROSPER: Depression Therapy Readiness Trial Data for Oncology Patients

A pragmatic, multicentre, assessor-blinded randomised controlled trial conducted from October 2024 to August 2025 in UK NHS cancer and primary care clinics. The dataset contains results from 160 participants with cancer and moderate-to-severe depression, evaluating a brief Treatment Preparation Intervention (TPI) against treatment as usual. The trial was registered as ISRCTN13692666 and completed in January 2026.

Use Cases

• Analyze the effectiveness of a brief motivational interviewing session on depression outcomes based on the primary outcome measure.
• Compare treatment effects between participants identified via case-finding versus those seeking care based on exploratory analysis results.
• Model longitudinal changes in depression scores across a 24-week follow-up period based on the trial design.
• Assess the safety profile of a psychological intervention based on reported adverse events.

Strengths

• Data from a prospectively registered (ISRCTN13692666) randomized controlled trial with a clear methodology.
• Includes 160 participants with an intention-to-treat analysis, providing a complete sample view.
• Findings are described as robust to sensitivity analysis, suggesting methodological rigor.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset size is 175.4 KB, indicating a very limited scope of data.

Provenance

Source

figshare, authored by Sam Malins.

Collection Method

Data collected from a pragmatic, multicentre, assessor-blinded randomised controlled trial.

Time Range

Trial recruitment from October 2024 to August 2025; follow-up to 24 weeks.

Freshness

Last updated 2026-04 07:42:58; freshness should be verified.

Geography

Four UK NHS cancer treatment centres and 24 NHS primary care clinics in the East Midlands region of England.