Cryptotanshinone Inhibition of Staphylococcus aureus NdhC: Experimental Data

129.0 MB of experimental data from a study on cryptotanshinone's selective inhibition of the NdhC enzyme in Staphylococcus aureus small colony variants (SCVs). The dataset includes antimicrobial assay results, in vitro enzymatic analysis, and molecular docking data, authored by Zhengjie Xue and last updated in April 2026. It supports research into overcoming antibiotic tolerance in drug-resistant bacterial infections.

Use Cases

• Validate selective enzyme inhibition based on antimicrobial assay results for NdhC and NdhF.
• Model drug-enzyme interactions based on molecular docking and site-directed mutagenesis data.
• Investigate collateral sensitivity in drug-tolerant SCVs based on susceptibility data for NDH-2 inhibitors.
• Analyze the role of specific mutations (e.g., perR, fusA) in antibiotic resistance phenotypes.

Strengths

• Data includes specific experimental results, such as a ≥2-fold enhanced collateral sensitivity to NDH-2 inhibitors.
• Contains multiple data types (TIF, JPG, XLSX) supporting different analysis methods.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Experimental research data from antimicrobial assays, enzymatic analysis, and molecular docking.

Freshness

Last updated 2026-04-12 07:30:33; freshness should be verified.