D-Lactic Acid Inhibition of Chlamydia Infectivity via Outer Membrane Disruption

Experimental data from a study investigating the antibacterial mechanism of D-lactic acid against Chlamydia trachomatis. The dataset likely contains results from in vitro and in vivo assays measuring outer membrane permeability, lipopolysaccharide release, and infection outcomes. Yunzhen Li published the data on figshare in May 2026.

Use Cases

• Analyze the correlation between D-lactic acid concentration and Chlamydia inhibitory activity based on the described positive correlation.
• Model the effect of outer membrane disruption on bacterial infectivity based on immunofluorescence and NPN fluorescence permeation data.
• Evaluate in vivo infection outcomes, such as chlamydial shedding and pathological damage, based on mouse challenge experiments.
• Assess the potential of D-lactic acid as an alternative or adjunctive therapy based on the described clinical rationale.

Strengths

• Data includes both in vitro and in vivo validation, as described in the summary.
• The dataset is published under a CC0-1.0 license, allowing unrestricted use.
• File size is 4.4 MB, indicating a manageable download.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains systematic validation data from laboratory experiments.

Freshness

Last updated 2026-05-25 14:19:17; freshness should be verified.