Microglia Genetic Targeting Data with CSF1R Inhibitor and T. gondii Infection Models

Data from a 2026 study by Tajie Harris on enhancing microglia-specific genetic targeting in mice. The dataset includes experimental results from combining tamoxifen induction in Cx3cr1CreERT2 mice with PLX5622 treatment and uses T. gondii brain infection models with time points ranging from days to months. Files are organized by experimental approach and require Microsoft Excel for viewing.

Use Cases

• Analyzing the specificity of gene deletion in microglia based on combined tamoxifen and PLX5622 treatment data.
• Comparing peripheral macrophage turnover rates across different post-treatment time points (e.g., 0,3,7,10,13 days).
• Investigating differential gene expression in microglia during T. gondii infection at various stages (e.g., 6 weeks, 8 days).
• Performing gene ontology enrichment analysis on the top differentially expressed genes from the associated GSE245107 dataset.

Strengths

• Dataset size is 3.2 GB, indicating a medium-scale collection of experimental data.
• Data is associated with a detailed methodological description involving specific mouse models and pharmacological treatments.
• Analysis pipeline is documented, including the use of R packages for differential expression and gene ontology enrichment.

Limitations

• Row count and specific column names are unknown, limiting pre-download assessment of data structure.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect experimental bias inherent to the specific mouse models and infection protocols used.

Provenance

Source

figshare, author Tajie Harris

Collection Method

Experimental data from mouse studies involving genetic manipulation, pharmacological treatment, and brain infection models.

Time Range

Experimental time points include 4 days, 4 weeks, 4 months, and specific days post-tamoxifen (0,3,7,10,13dpt).

Freshness

Last updated 2026-04-23 18:26:33