Carotid Body ATP Transmission and Glomus Cell Data from Rat Hypertension Study

Igor Felippe's dataset, last updated in April 2026, contains experimental results from a study comparing spontaneously hypertensive rats (SHRs) to Wistar rats. The data likely includes quantified ATP release, morphometric analysis of glomus tissue, mRNA transcript levels, and electrophysiological reflex measurements. The file is 114.9 KB in size and is available under a CC-BY-4.0 license.

Use Cases

• Compare ATP release levels between hypertensive and normotensive rat strains based on the described in vitro CB preparations.
• Analyze the relationship between glomus cell expansion and upregulated Epas1 mRNA based on the morphometric and transcript data.
• Investigate the correlation between downregulated ATP-degrading enzyme transcripts and increased purinergic drive in SHRs.
• Model chemoreflex sensitivity differences between strains using the described electrophysiological and reflex testing results.

Strengths

• Includes statistically significant results (e.g., P = 0.00062 for ATP release, P = 5.44 × 10⁻⁶ for glomus tissue area).
• Data is derived from controlled experimental comparisons with specified sample sizes (e.g., n = 10, n = 8, n = 4).
• Covers multiple analytical methods: ATP quantification, morphometry, transcript analysis, and electrophysiology.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's 114.9 KB size indicates a very limited scope, likely containing summary results rather than raw observations.

Provenance

Source

figshare

Collection Method

Data generated from in vitro and in situ experiments on rat carotid body preparations, as described.

Time Range

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Freshness

Last updated 2026-04-08 23:05:24; freshness should be verified.

Geography

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