Dectin-1 and TLR2 Nanocluster Data for Synergistic Immune Signaling

Finite-size nanoclusters of Dectin-1 and TLR2 set a minimum endosome size for synergistic immune signaling. The dataset, shared by Jinyan Cui on figshare, contains data supporting the finding that larger pathogen-derived cargos generate endosomal membranes with sufficient area to accommodate both receptor nanoclusters, enabling amplified inflammatory responses. The data was last updated on 2026-05-26.

Use Cases

• Modeling the relationship between endosome size and receptor co-localization based on the described experimental setup with nanoparticles and extracellular vesicles.
• Analyzing the balance of inter-receptor attraction and repulsion that maintains discrete nanoclusters, as informed by the computational modeling results.
• Investigating how pathogen cargo size is converted into immune signaling decisions based on the described physical gating mechanism.

Strengths

• Data is associated with a specific, peer-reviewed biological mechanism described in the summary.
• The dataset is openly available under a CC-BY-4.0 license.
• File size is 94.4 KB, allowing for quick download and inspection.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's 94.4 KB size indicates a very limited scope, likely containing summary or model results rather than raw experimental data.

Provenance

Source

Jinyan Cui via figshare.

Collection Method

Likely contains experimental and computational modeling results from the described study using ligand-functionalized nanoparticles and fungus-derived extracellular vesicles.

Freshness

Last updated 2026-05-26 06:17:28; freshness should be verified.