Histamine Signaling Gene Families Across 89 Metazoan Proteomes

89 proteomes spanning major metazoan lineages were analyzed to reconstruct the evolutionary history of the histaminergic signaling system. The study, authored by Ankit Thakur and last updated in June 2026, used homology searches, phylogenetic reconstruction, and gene tree–species tree reconciliation. It focuses on core gene families involved in histamine biosynthesis, degradation, transport, and signaling.

Use Cases

• Evolutionary analysis of histamine biosynthesis pathways based on gene family data
• Comparative genomics of histamine degradation enzymes across metazoan lineages
• Phylogenetic reconstruction of histamine receptor diversification
• Gene tree–species tree reconciliation to infer evolutionary events in signaling systems
• Domain validation and classification of histamine-related transport proteins

Strengths

• Analyzes 89 proteomes, providing a broad taxonomic sampling across Metazoa
• Includes core gene families for biosynthesis, degradation, transport, and signaling, offering a multi-component view
• Data is openly available under a CC-BY-4.0 license

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment for certain analyses

Provenance

Source

figshare

Collection Method

Homology searches, domain validation, phylogenetic reconstruction, rogue taxon filtering, and gene tree–species tree reconciliation.

Freshness

Last updated 2026-06-01 03:07:10; freshness should be verified