Genomic Epidemiology of Multidrug-Resistant Klebsiella Pneumoniae in Chinese Cattle

182 Klebsiella pneumoniae isolates from bovine feces across 13 Chinese provinces underwent antimicrobial susceptibility testing and whole-genome sequencing. The data reveals 54.95% imipenem resistance, 84 acquired resistance gene families, and 67 distinct sequence types (STs), with 72 isolates forming four inter-provincial transmission clusters based on a core-genome SNP threshold.

Use Cases

• Analyze the correlation between phenotypic antimicrobial susceptibility results and the genomic resistome of 84 gene families.
• Track the inter-provincial dissemination of dominant lineages like ST37 and ST1537 using core-genome SNP profiling.
• Investigate the prevalence of specific resistance determinants, such as blaSHV subtypes, across 67 different sequence types.
• Model the transmission networks of multidrug-resistant clones using the ≤18 core-genome SNP threshold applied to 182 isolates.

Strengths

• Includes genomic and phenotypic data for 182 bacterial isolates, providing a dual perspective on resistance.
• Spatial coverage spans 13 provinces in China, enabling analysis of national-scale transmission.
• Data identifies 67 distinct sequence types and four high-confidence inter-provincial transmission clusters.

Limitations

• The dataset is limited to 182 isolates, which may not be representative of the entire bacterial population in Chinese cattle.
• Temporal coverage is not specified, limiting longitudinal analysis of resistance evolution or spread.
• Focus is exclusively on bovine-origin Klebsiella pneumoniae from China, reducing generalizability to other hosts or geographies.

Provenance

Source

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Collection Method

Isolates recovered from bovine feces, subjected to antimicrobial susceptibility testing and whole-genome sequencing.

Time Range

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Freshness

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Geography

13 provinces across China