Integrin β3 Sialylation Data for HCMV Entry into Fibroblasts

Research data from a 2026 study investigating the role of α2,6-sialylation of Integrin β3 in Human cytomegalovirus (HCMV) entry into fibroblasts. The dataset, shared by author Taowen Pan on figshare, includes results from quantitative PCR, flow cytometry, immunofluorescence, and virological assays. It supports findings on how the sialyltransferase ST6Gal1 modifies Integrin β3 to facilitate viral internalization and signaling.

Use Cases

• Analyzing the relationship between Integrin β3 glycomics and viral entry efficiency based on glycomics database analysis mentioned in the description
• Modeling the impact of ST6Gal1 knockdown on HCMV infection rates based on established knockout and knockdown cell models
• Investigating Integrin-Src and Rho A-cofilin signaling pathway activation during viral entry based on mechanistic analysis described

Strengths

• Data is associated with a specific, peer-reviewed research question on HCMV entry mechanisms.
• Includes results from multiple experimental methods: quantitative PCR, flow cytometry, immunofluorescence, and virological assays.
• Available under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 30.0 MB size suggests a relatively small dataset, potentially limiting statistical power for some analyses.

Provenance

Source

figshare

Collection Method

Experimental research involving glycomics database analysis, cell line engineering (knockout/knockdown), and virological assays.

Freshness

Last updated 2026-04-21 07:49:22; freshness should be verified.