Toxoplasma Gondii HLA-A*02:01 Peptide Ligands Identified via Immunopeptidomics

Ruiying Liang published a dataset on figshare in May 2026 detailing Toxoplasma gondii peptides presented by HLA-A*02:01. The dataset includes a foundational ligandome of 3,433 high-confidence parasite-derived peptides identified through mass spectrometry in transgenic mice. It provides a prioritized list of 73 high-affinity candidates for further immunological study.

Use Cases

• Prioritizing vaccine candidate peptides based on the list of 73 high-affinity HLA-A*02:01 ligands.
• Studying stable MHC-I presentation across infection stages based on ligands detected in both acute and chronic phases.
• Analyzing source protein diversity based on peptides originating from diverse parasite proteins, including hypothetical ones.
• Validating in silico prediction models using the experimentally confirmed peptide binding data.

Strengths

• Provides a high-confidence foundational ligandome of 3,433 unique Toxoplasma gondii-derived peptides.
• Includes experimental validation of HLA-A*02:01 binding for five prioritized candidates.
• Contains structural data with a co-crystal structure for a novel ligand from glycogen synthase.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific HLA-A*02:01 transgenic mouse model used.

Provenance

Source

Ruiying Liang

Collection Method

Mass spectrometry-based immunopeptidomics in HLA-A2.1 transgenic mice.

Freshness

Last updated 2026-05-13 07:05:22; freshness should be verified.