Mouse Kidney Metabolomics After Chronic BPA Exposure

Chronic exposure to Bisphenol A at 50 mg/kg/day for 3 months induced metabolic reprogramming in mouse kidney tissue. Untargeted LC-MS metabolomics data from 14 mice (8 exposed, 6 control) reveals alterations in lipid metabolism, mitochondrial fatty acid oxidation, and steroid hormone pathways. The dataset integrates with histopathological observations and previously reported transcriptomic changes.

Use Cases

• Identifying metabolic pathway disruptions based on differentially abundant metabolites and KEGG enrichment analysis.
• Correlating metabolomic signatures with histopathological observations of renal tissue.
• Integrating metabolomic findings with transcriptomic data to understand BPA's functional metabolic impact.
• Investigating mitochondrial dysfunction based on altered acylcarnitine and fatty acid oxidation profiles.

Strengths

• Data is derived from a controlled in vivo study with a defined exposure regimen (50 mg/kg/day for 3 months).
• Analysis integrates multiple data layers: untargeted metabolomics, histopathology, and prior transcriptomics.
• Dataset is openly available under a CC-BY-4.0 license, facilitating reuse.

Limitations

• Column names and the exact number of data rows are not provided in the source metadata.
• The dataset is relatively small in sample size, with 14 mice total.
• The temporal coverage is limited to a single 3-month exposure period.

Provenance

Source

Marta MAJEWSKA

Collection Method

Untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics performed on kidney samples from BPA-exposed and control mice.

Time Range

3-month exposure period.

Freshness

Last updated on 2026-03-21.

Geography

Laboratory mouse study; specific location not stated.