KCNJ11 Polymorphism and Type 2 Diabetes: Egyptian Case-Control Study

200 participants, including 100 Type 2 diabetes patients and 100 matched controls, were analyzed for KCNJ11 rs5215 polymorphism. The dataset includes clinical, anthropometric, and biochemical data collected by AbdelRahhman Ali and last updated in June 2026. Results indicate an association between the TT genotype and T allele and T2DM susceptibility, though modifiable metabolic factors were stronger predictors.

Use Cases

• Assessing genetic susceptibility to Type 2 diabetes based on KCNJ11 rs5215 genotype
• Comparing clinical and biochemical profiles between diabetic patients and healthy controls
• Investigating the relationship between diabetic nephropathy and specific genetic markers
• Evaluating the predictive power of modifiable metabolic factors versus genetic markers for disease risk

Strengths

• Dataset includes 200 participants with age- and sex-matched case-control design
• Genotyping was performed using PCR-RFLP and confirmed by Sanger sequencing
• Analysis includes multivariate assessment of independent predictors like BMI, blood glucose, and LDL cholesterol

Limitations

• Row count and specific column-level documentation are absent; field semantics must be inferred after download
• The dataset is small at 1.8 MB, which may limit statistical power for some analyses
• Data reflects a specific Egyptian cohort, which may limit generalizability to other populations

Provenance

Source

figshare

Collection Method

Case-control study with data collected via clinical, anthropometric, and biochemical assessments.

Freshness

Last updated 2026-06-03 21:44:00

Geography

Egypt