LTBP4 Loss in Ossification of Ligamentum Flavum: Dynamic Transcriptomic Profiles

Nine RNA sequencing samples from three patients with multi-segment ossification of the ligamentum flavum (OLF) depict the dynamic transcriptomic landscape across normal, immature, and mature OLF tissue stages. The dataset includes differential expression, functional enrichment, and dynamic trend analyses. Author Xiao Zhang published the 8.0 MB XLSX file on figshare under a CC-BY-4.0 license in May 2026.

Use Cases

• Identify differentially expressed genes associated with ossification of ligamentum flavum (OLF) progression based on the described RNA-seq data.
• Conduct functional enrichment analysis to discover biological pathways involved in OLF based on the described transcriptomic profiles.
• Model the dynamic transcriptional trends across normal, immature, and mature OLF tissue stages based on the described sample stratification.

Strengths

• Includes 9 RNA sequencing samples from 3 patients, providing a multi-stage view of the disease.
• Analysis includes differential expression, functional enrichment, and dynamic trend analysis, suggesting a structured investigation.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Sample size of 3 patients may limit the generalizability of findings.

Provenance

Source

figshare

Collection Method

RNA sequencing of tissue samples from three multi-segment OLF patients.

Freshness

Last updated 2026-05-28 11:21:21; freshness should be verified.