Microgravity-Induced Mitotic Transcription-DNA Synthesis Conflict Data

Genomic data from human epithelial cells exposed to microgravity on the International Space Station and in simulated conditions. The dataset, authored by Youhang Li and released under CC-BY-4.0, investigates R-loop homeostasis, transcription-replication conflicts, and mitotic DNA synthesis. It was last updated on June 4, 2026.

Use Cases

• Analyzing R-loop accumulation under microgravity based on R-loop processing factor depletion mentioned in the description
• Investigating transcription-replication conflicts based on the described shift towards a BIR-like repair mode
• Studying mitotic DNA synthesis (MiDAS) based on the reported increase under replication stress
• Examining the role of DHX36 and TRIP12 in suppressing mitotic transcription-DNA synthesis conflict (MiTRC)

Strengths

• Data includes samples returned from the International Space Station, providing real microgravity exposure.
• Analysis includes both spaceflight and ground-based simulated microgravity conditions for comparison.
• The dataset is 206.8 MB in size, suggesting substantial underlying data.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale statistical analysis.

Provenance

Source

figshare

Collection Method

Analyses of space station-returned samples and simulated microgravity-treated cells.

Freshness

Last updated 2026-06-04 08:51:11; freshness should be verified.