miR-483 Deficiency in Pancreatic β-Cells: Mouse Model Data

Xiaoqing Tang published a dataset on figshare in May 2026 describing research into miR-483 deficiency in pancreatic β-cells. The dataset likely contains findings from mouse models, including scRNA-seq results, showing β-cell dedifferentiation and aberrant glucagon production under dietary and chemical stress. The data is stored in a PDF file of 2.8 MB.

Use Cases

• Study β-cell dedifferentiation mechanisms based on lineage-tracing evidence mentioned in the description
• Analyze stress-induced transcriptional reprogramming based on scRNA-seq findings
• Investigate the link between mitochondrial fragmentation and β-cell dysfunction based on described metabolic changes
• Model the role of miR-483 in preserving β-cell identity based on knockout mouse phenotypes

Strengths

• Dataset is associated with a specific, detailed research hypothesis on miR-483
• Includes data from multiple experimental approaches: knockout mice, high-fat diet, streptozotocin stress, and single-cell RNA sequencing
• Published under an MIT license, allowing for broad reuse

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The primary data format is PDF, which may not be directly machine-readable for analysis

Provenance

Source

figshare

Collection Method

Likely contains experimental data from mouse models and single-cell RNA sequencing.

Freshness

Last updated 2026-05-03 05:29:15