Mitochondrial Proteome Perturbation in Aging Mouse Organs

Mitoprotein importation stress contributes to mitochondrial dysfunction during aging, but the specific proteins involved are not well understood. This dataset provides a proteomic analysis of mitochondria-specific proteins from nine organs in 3-month and 20-month-old mice, comparing proteins inside and outside the organelles. The data was generated by Qing Gao and includes mass spectrometry results for mitochondrial and cytoplasmic proteins, alongside evaluations of mitochondrial morphology and health.

Use Cases

• Identify age-related mitoprotein accumulation based on proteomic signatures from nine organs.
• Analyze mitochondrial dysfunction based on comparative proteome data from young and old mice.
• Study organ-specific aging patterns based on mitochondrial protein perturbation across different tissues.
• Investigate the relationship between mitoprotein import stress and morphology based on paired health status evaluations.

Strengths

• Compares proteomic data from two distinct age groups: 3-month and 20-month-old mice.
• Includes samples from nine different mouse organs, allowing for organ-specific analysis.
• Pairs mass spectrometry data with independent evaluations of mitochondrial morphology and health.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale modeling.

Provenance

Source

Qing Gao via figshare

Collection Method

Mitochondria were extracted from mouse organs, and proteins were analyzed via mass spectrometry.

Freshness

Last updated 2026-05-25 09:37:58; freshness should be verified.