MOV10 and RABV N Protein Interaction Data for Viral Replication Restriction

Experimental data from a study demonstrating the interaction between the host protein MOV10 and the rabies virus nucleoprotein (N) in an RNA-dependent manner. The dataset, authored by Yumeng Song and last updated on 2026-04-22, likely contains results from bimolecular fluorescence complementation, confocal microscopy, and a dual-luciferase reporter system. It supports the finding that MOV10 sequesters viral N-RNA templates into P-bodies to block RABV replication.

Use Cases

• Analyzing protein-protein interaction strength based on fluorescence complementation assay data
• Modeling viral polymerase inhibition based on dual-luciferase reporter system results
• Studying subcellular localization of viral complexes based on confocal microscopy data
• Investigating the functional impact of specific mutations like E647Q on antiviral activity

Strengths

• Data is associated with a detailed mechanistic study published on figshare.
• The 2.6 MB XLSX file suggests a structured, tabular format for analysis.
• The study employs multiple validation methods, including mutagenesis and microscopy.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Yumeng Song

Collection Method

Likely contains experimental results from cell culture studies, protein interaction assays, and luciferase reporter systems.

Freshness

Last updated 2026-04-22 08:00:50; freshness should be verified.