Rat Model Data on Heart-Lung Neural Crosstalk in Chronic Heart Failure

Experimental data from a rat model of myocardial infarction investigating neural mechanisms of heart-lung crosstalk. The dataset includes molecular profiling, immunofluorescence, tissue clearing, and functional assay results, totaling 464.8 MB in TIF, PNG, and other formats. It was authored by Hanjun Wang and last updated on April 23, 2026.

Use Cases

• Analyzing macrophage infiltration and glial activation in thoracic dorsal root ganglia based on immunofluorescence and tissue clearing data.
• Studying the suppression of voltage-gated potassium (Kv) channels and neuron excitability based on functional assay results.
• Evaluating the effects of anti-inflammatory interventions like minocycline and ProGel-Dex on reflex responses and cardiac dilation.
• Investigating cardiac afferent-mediated cytokine transport to DRGs based on epicardial injection assay data.

Strengths

• Dataset size is 464.8 MB, indicating a medium-scale collection of raw experimental files.
• Includes multiple data modalities such as images (TIF, PNG) and analysis files (PZFX, PRISM) from molecular and functional assays.
• License is CC-BY-4.0, permitting broad reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.
• Data is derived from a specific rat model, which may limit direct translation to human physiology.

Provenance

Source

figshare

Collection Method

Data generated from laboratory experiments including coronary ligation in rats, molecular profiling, immunofluorescence, and functional assays.

Freshness

Last updated 2026-04-23 18:36:37; freshness should be verified.