Neurofunctional fMRI Data from a UK RCT on Trigeminal Nerve Stimulation for ADHD

A UK multicentre randomized controlled trial tested the neurofunctional effects of Trigeminal Nerve Stimulation (TNS) on 62 children and adolescents with ADHD. The dataset includes fMRI data from three ADHD-sensitive tasks assessing response inhibition, working memory, and sustained attention. Natali Bozhilova published the data on figshare in May 2026 under a CC-BY-4.0 license.

Use Cases

• Analyze task-related brain activation patterns based on fMRI data from response inhibition, working memory, and sustained attention tasks.
• Compare neurofunctional outcomes between real and sham stimulation groups based on the rigorous sham control condition described.
• Investigate the relationship between brain activation and clinical symptoms in ADHD based on the secondary mechanistic analysis of the RCT.

Strengths

• Dataset size is 14.2 GB, indicating a substantial volume of neuroimaging data.
• Data originates from a larger multicentre 4-week UK randomized controlled trial with 62 participants.
• Uses a rigorous sham control condition and three standardized fMRI tasks for mechanistic analysis.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The study found no significant effect of TNS on brain activation or task performance, which may limit its utility for validating TNS efficacy.

Provenance

Source

figshare

Collection Method

Secondary mechanistic analysis of a randomized controlled trial using fMRI.

Time Range

The trial duration was 4 weeks; specific collection dates are not provided.

Freshness

Last updated 2026-05-02 10:55:30; freshness should be verified.

Geography

United Kingdom (UK multicentre trial).