Bacteriophage vB_EcoP_GZMU_E1004 and Baicalin Synergy Data for Drug-Resistant E. coli

A 39,250 bp double-stranded DNA genome characterizes the novel Kayfunavirus phage vB_EcoP_GZMU_E1004, isolated to target drug-resistant Escherichia coli. The dataset, published by 斯芳 窦 on figshare in April 2026, includes results on phage stability, host range, and synergistic antibacterial effects when combined with the natural compound baicalin.

Use Cases

• Modeling phage-bacteria interaction dynamics based on host range coverage and lysis rate data.
• Analyzing synergistic drug effects based on Fractional Inhibitory Concentration (FIC) index results.
• Studying phage stability for therapeutic applications based on temperature and pH tolerance ranges.
• Investigating biofilm inhibition strategies based on results from combination therapy experiments.

Strengths

• Phage genome lacks virulence or resistance genes, suggesting a favorable safety profile.
• Phage exhibits stability across a 4–50°C temperature range and pH 4–10.
• Synergy with baicalin reduced effective agent concentrations by 10-fold and ~8-fold.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (84.2 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Experimental isolation and characterization of a novel bacteriophage, combined with in vitro synergy testing.

Time Range

Experimental study timeframe not specified.

Freshness

Last updated 2026-04-14 10:12:39; freshness should be verified.

Geography

Geographic origin of the phage or bacterial strains is not specified.