Renal Transporter Profiles in Male and Female Hypertensive Rats

Alicia McDonough's 2026 study profiles renal transporter and channel abundance in 14-week-old male and female spontaneously hypertensive rats (SHR). The dataset, shared on figshare, compares these profiles to normotensive Sprague Dawley rats under high-salt diet and angiotensin II-induced hypertension conditions. It contains 1.6 MB of data, likely in tabular form, supporting integrative analysis of sex differences in hypertensive models.

Use Cases

• Compare sexual dimorphic patterns of renal transporter abundance based on profiles from hypertensive and normotensive rat models.
• Analyze the relationship between pressure-natriuresis responses and transporter activation based on integrative analysis across conditions.
• Investigate differences in distal nephron versus proximal sodium transporter patterns based on semi-quantitative immunoblot data.

Strengths

• Data is derived from a controlled experimental study profiling specific renal transporters and channels.
• Includes a comparative analysis across multiple conditions (SHR, normotensive SD, high-salt diet, AngII-HTN).
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 1.6 MB size suggests a relatively small-scale dataset.

Provenance

Source

figshare

Collection Method

Data likely generated via semi-quantitative immunoblots of renal tissue from laboratory rats.

Freshness

Last updated 2026-06-02 20:11:52; freshness should be verified.