Supporting Data for Sjögren's Syndrome γδT17 Cell AQP3-H2O2 Axis Study

Supporting data for a study investigating the role of Aquaporin-3 (AQP3) in IL-17-producing γδ T cells in Sjögren's syndrome. The dataset was published by Mengna Zhao on figshare under a CC-BY-NC-4.0 license and was last updated on 2026-05 06. It likely contains transcriptomic and experimental results from mouse models and patient samples.

Use Cases

• Analyze transcriptomic signatures of γδT17 cells compared to other T cell subsets based on the described profiling.
• Investigate the link between AQP3 expression, hydrogen peroxide transport, and IL-17 production based on the described mechanistic axis.
• Study metabolic reprogramming in T cells based on the described mitochondrial respiration and ATP production data.
• Validate molecular checkpoints for γδT17 cell pathogenicity in autoimmune models based on the described genetic and pharmacological inhibition results.

Strengths

• Data supports a peer-reviewed study with a defined mechanistic axis (AQP3-H2O2) and functional validation.
• Includes results from both human patient samples (peripheral blood, labial glands) and a controlled mouse model (ESS).
• License is clearly specified as CC-BY-NC-4.0, defining reuse terms.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count and file formats are unknown, which may limit suitability assessment.
• Data may reflect experimental bias inherent to the specific figshare study's methodology.

Provenance

Source

figshare

Collection Method

Likely generated from laboratory experiments including transcriptomic profiling, cell culture, and animal models as described.

Time Range

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Freshness

Last updated 2026-05-06 09:22:29; freshness should be verified.

Geography

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