Supporting Data for TACE-Induced Immune Microenvironment Remodeling in HCC

A dataset supporting a study investigating how Transarterial Chemoembolization (TACE) remodels the immunosuppressive tumor microenvironment in hepatocellular carcinoma. The data likely includes results from CUT&Tag, spatial transcriptomics, and multiplex immunohistochemistry analyses conducted in murine models. The dataset was authored by Jinyang Li and last updated on June 1, 2026.

Use Cases

• Analyze cholesterol-mediated macrophage activation based on CUT&Tag and ABCA1 expression data
• Model spatial distribution of immunosuppressive macrophages based on spatial transcriptomics and multiplex immunohistochemistry results
• Investigate hypoxia-driven impairment of tertiary lymphoid structures based on HIF-1α and PD-L1 expression data
• Evaluate therapeutic synergy between ABCA1 inhibition and anti-PD-L1 therapy based on murine model outcomes

Strengths

• Dataset supports a detailed mechanistic study published on figshare
• Analysis integrates multiple techniques: CUT&Tag, spatial transcriptomics, and multiplex immunohistochemistry
• License is CC-BY-NC-4.0, allowing for non-commercial reuse

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect bias inherent to the specific murine models and experimental conditions used

Provenance

Source

figshare

Collection Method

Likely generated from laboratory experiments including murine TACE models, molecular assays, and imaging.

Freshness

Last updated 2026-06-01 01:46:03; freshness should be verified