Experimental Data for Synthesis of Axially Chiral Biaryls via Lithium Cuprate Catalysis

Jiamao Hao's thesis data on a catalytic method for synthesizing tri- and tetra-ortho-substituted axially chiral biaryls. The dataset includes PDF and TXT files totaling 27.5 MB, supporting research on enantioselective desymmetrization and derivatization reactions. It was last updated on June 1, 2026.

Use Cases

• Developing asymmetric catalysts based on the described tetra-ortho-substituted biaryl aldehydes.
• Studying enantioselectivity in desymmetrization reactions based on the reported >99% e.e. values.
• Designing functional molecules with novel biaryl frameworks based on described derivatization reactions.
• Analyzing substrate scope and reaction conditions for modular construction of C–C, C–O, or C–N axially chiral compounds.

Strengths

• Includes data on reactions achieving enantioselectivity up to 99% e.e.
• Describes a catalytic system with a wide substrate scope and mild reaction conditions.
• Provides data on the synthesis of tetra-ortho-substituted biaryls with excellent axial chirality stability.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect methodological bias inherent to the specific synthetic approach.

Provenance

Source

figshare

Collection Method

Experimental research data from a doctoral thesis.

Freshness

Last updated 2026-06-01 01:47:36; freshness should be verified.