HMGB1 Protein Synthesis Data for Post-translational Modification Studies

Supporting data details the total chemical synthesis of the High Mobility Group Box 1 (HMGB1) protein. Two synthetic routes were developed for fully reduced and disulfide HMGB1, with homogeneous glycosylated and acetylated variants created to study biological effects on receptor binding and cell chemotaxis.

Use Cases

• Comparing receptor binding affinity based on homogeneous acetylated HMGB1 variants
• Analyzing cell chemotaxis effects based on homogeneous glycosylated HMGB1 variants
• Evaluating synthetic route efficiency for fully reduced versus disulfide HMGB1

Strengths

• Dataset provides data on homogeneous, chemically synthesized protein variants, which are difficult to produce biologically
• Cross-platform presence on figshare suggests curated, reusable research data

Limitations

• Column names and dataset size are unknown, limiting understanding of its structure
• No specific row count or file formats are provided

Provenance

Source

Zhixiang Zhong

Collection Method

Likely generated from laboratory experiments on chemical protein synthesis

Freshness

Last updated on 2026-03-18