Experimental Data on Urolithin A's Cardioprotective Effects in Sepsis Models

A dataset from figshare by Bingqing Ye, last updated April 2026, containing experimental results on sepsis-induced myocardial injury. The 1.3 MB dataset includes data from rat models and cardiac cell studies, published under a CC-BY-4.0 license. It likely contains measurements from survival analysis, cytokine levels, and apoptosis assays.

Use Cases

• Validate the cardioprotective effects of Urolithin A based on survival and organ index data from rat models.
• Analyze the relationship between IDH1 activity and apoptosis based on flow cytometry and TUNEL staining results.
• Model the Bcl-2-associated apoptotic pathway based on metabolite and signaling data from in vivo and in vitro experiments.

Strengths

• Data is derived from a multi-method study combining in vivo (rat CLP model) and in vitro (H9C2 cell) experiments.
• The molecular target (IDH1) was identified using integrated network pharmacology, molecular docking, and CETSA assays.
• Includes results from functional validation via shRNA knockdown and pharmacological inhibition.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• The dataset is small at 1.3 MB, which may limit the scope of analysis.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Bingqing Ye via figshare

Collection Method

Experimental data from cecal ligation and puncture (CLP) rat models and LPS-stimulated H9C2 cardiac cells.

Freshness

Last updated 2026-04-28 05:59:27; freshness should be verified.