Meta-Analysis of Risk Factors and Prognosis in Cutaneous Squamous Cell Carcinoma

A meta-analysis by piao H, last updated in May 2026, aggregates data from 24 cohort studies involving 142,903 patients with cutaneous squamous cell carcinoma. It evaluates the impact of clinicopathological features on recurrence, metastasis, and disease-specific death. The dataset includes pooled risk ratios and is available in NBIB, RIS, and XLSX formats.

Use Cases

• Identify high-risk patient subgroups based on features like poor differentiation and immunosuppression mentioned in the description.
• Compare treatment outcomes between Mohs micrographic surgery and standard excision as discussed in the meta-analysis.
• Validate prognostic models for cutaneous squamous cell carcinoma using the pooled risk ratios for recurrence and metastasis.
• Guide clinical trial design by understanding the independent prognostic impact of factors such as tumour size and perineural invasion.

Strengths

• Aggregates data from 142,903 patients across 24 cohort studies, providing a substantial evidence base.
• Analyzes multiple prognostic endpoints including recurrence, metastasis, and disease-specific death.
• Uses random-effects models to generate pooled risk ratios with 95% confidence intervals.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The description notes inconsistent advantages for Mohs surgery, indicating potential heterogeneity in the underlying studies.
• Data freshness should be verified; last updated 2026-05-19 15:22:21.

Provenance

Source

piao H via figshare.

Collection Method

Meta-analysis of cohort studies sourced from four databases up to September 2025.

Time Range

Studies searched through September 2025.

Freshness

Last updated 2026-05-19 15:22:21.