Meta-sGWAS: Bipolar Disorder Genetic Associations with Brain Spatial Interactions

Aq Wang's 1.0 GB dataset, last updated April 13, 2026, presents results from a spatial-informed genome-wide association study (Meta-sGWAS) for bipolar disorder. It integrates multimodal brain MRI and genomic data from the Adolescent Brain Cognitive Development (ABCD) study and UK Biobank to uncover genetic variants linked to brain regional interactions. The dataset includes GWAS results with and without brain structural traits from both cohorts.

Use Cases

• Validate genetic associations for bipolar disorder based on identified brain regions of interest like the right subcallosal gyrus.
• Compare standard GWAS versus spatial-informed GWAS performance based on the provided ABCD and UK Biobank result sets.
• Investigate cell-type-specific genetic risk signals based on single-nucleus RNA-seq validation findings for cortical interneuron subtypes.
• Prioritize candidate genes like CACNA1C and TRANK1 based on enhanced association signals from the Meta-sGWAS framework.

Strengths

• Dataset size is 1.0 GB, indicating substantial content.
• Results are validated across two major cohorts: ABCD and UK Biobank.
• Specific brain regions with significant p-values are identified, such as the right subcallosal gyrus (P = 9.9 x 10^-9).
• License is CC-BY-4.0, allowing for broad reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic or cohort bias inherent to the ABCD and UK Biobank sources.

Provenance

Source

figshare, authored by Aq Wang.

Collection Method

Derived from applying the Meta-sGWAS framework to multimodal brain MRI and genomic data from the ABCD study and UK Biobank.

Time Range

Temporal coverage of the underlying ABCD and UK Biobank data is not specified.

Freshness

Last updated 2026-04-13 12:21:20; freshness should be verified.

Geography

Spatial coverage is likely focused on the populations represented by the ABCD (U.S.) and UK Biobank (U.K.) studies.